Defluoroalkylation of gem-Difluoroalkenes with Alcohols via C-F/C-H Coupling
Congjian Xia1, Haiyang Hu2, Wengang Xu1
1College of New Energy, State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), 266580 Qingdao, P. R. China.
Abstract:
A feasible and effective method to synthesize α-fluoroalkenyl alcohols was reported. With the cooperation of photoredox and hydrogen atom transfer (HAT) processes, defluoroalkylations of gem-difluoroalkenes occurred smoothly with alcohols under visible-light irradiation. Notably, the protocols feature broad scopes, mild conditions, and validity for the late-stage functionalization of bioactive molecule derivatives. Mechanistic studies suggested that the reaction occurred through the radical coupling of the alkyl radical and the fluoroalkenyl radical.
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