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Evaluation of Vitamin D Level in Children With Febrile Seizure Referred to Amirkola Children's Hospital, Babol

Mohsen Mohammadi1, Yeganeh Baleghi1, Mohammadreza Salehiomran1

  • 1Babol University of Medical Sciences, Babol, Iran.

Global Pediatric Health
|December 25, 2023
PubMed

Insights

This study found no significant difference in vitamin D levels between children with and without febrile seizures. Vitamin D deficiency was common in both groups, suggesting no direct correlation with febrile seizure incidence.

Area of Science:

  • Pediatrics
  • Biochemistry
  • Neurology

Background:

  • Febrile seizures are common in children.
  • Vitamin D plays a role in various physiological processes.
  • The relationship between vitamin D levels and febrile seizures requires further investigation.

Purpose of the Study:

  • To evaluate the association between vitamin D levels and the incidence of febrile seizures in children.
  • To compare vitamin D, calcium, phosphorus, and alkaline phosphatase levels in children with and without febrile seizures.

Main Methods:

  • A case-control study involving 90 febrile children.
  • Children were divided into case (with seizures) and control (without seizures) groups.
  • Assessed serum levels of vitamin D, calcium, phosphorus, and alkaline phosphatase.

Main Results:

  • No significant difference in mean vitamin D levels between case and control groups (P=.62).
  • Higher mean alkaline phosphatase levels were observed in the case group (P=.04).
  • Vitamin D deficiency and insufficiency were prevalent in both groups, without significant difference (P=.17).

Conclusions:

  • Mean vitamin D levels and deficiency rates did not significantly differ between children with and without febrile seizures.
  • No correlation was found between vitamin D levels and the incidence of febrile seizures in this cohort.
  • Elevated alkaline phosphatase in the seizure group warrants further research.

Keywords:
childrenfebrile seizurevitamin D

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