The Recent Advances in Iron-Catalyzed C(sp³ )-H Functionalization

Area of Science:

• Organometallic Chemistry
• Catalysis
• Organic Synthesis

Background:

• Iron is the most abundant, inexpensive, and biocompatible transition metal, making it an attractive alternative to noble metals in catalysis.
• Direct C-H functionalization is a key strategy for modifying organic molecules, particularly those containing abundant C(sp3)-H bonds.

Purpose of the Study:

• To review the application of iron catalysts in direct C(sp3)-H bond activation.
• To summarize the substrate scope, selectivity, benefits, and limitations of iron-catalyzed C(sp3)-H activation protocols up to 2022.

Main Methods:

• Literature review of iron-catalyzed C(sp3)-H activation studies.
• Analysis of substrate scope, reaction conditions, and catalytic performance.

Main Results:

• Iron catalysts demonstrate significant potential for various C(sp3)-H functionalization reactions.
• The review highlights the versatility and growing importance of iron in catalysis for C-H activation.

Conclusions:

• Iron catalysis presents a sustainable and economical approach for C(sp3)-H bond activation, offering a viable alternative to precious metal catalysts.
• Further research into iron catalysis can unlock new possibilities in organic synthesis and drug discovery.