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Multiple sclerosis-associated uveitis - A series from South India
Kalpana Babu1, Geethanjali C Janardhana2, Krishna R Murthy1,2
1Department of Uveitis and Ocular Inflammation, Prabha Eye Clinic and Research Centre and Vittala International Institute of Ophthalmology, Bengaluru, Karnataka, India.
Indian Journal of Ophthalmology
|December 28, 2023
Summary
This study details seven cases of multiple sclerosis (MS)-associated uveitis in India, noting intermediate uveitis as the most common form. The findings highlight the clinical profiles and good visual outcomes in this underreported condition.
Area of Science:
- Ophthalmology
- Neurology
- Genetics
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Ocular manifestations, including uveitis, can occur in MS patients.
- MS-associated uveitis is considered underreported, particularly in India.
Purpose of the Study:
- To describe the clinical characteristics of multiple sclerosis (MS)-associated uveitis.
- To report on seven cases from a tertiary eye care center in South India.
- To contribute to the understanding of this underreported condition in the Indian subcontinent.
Main Methods:
- Retrospective case series conducted between 2013 and 2023.
- Analysis of clinical data from seven confirmed cases of MS-associated uveitis.
- Inclusion of demographic, clinical presentation, treatment, and outcome data.
Main Results:
- Seven cases (five female, two male) of MS-associated uveitis were identified.
- Intermediate uveitis was the most frequent presentation (five cases), often with retinal vasculitis or disc pallor.
- Other presentations included Fuchs heterochromic iridocyclitis and an incomplete Vogt-Koyanagi-Harada-like syndrome.
- Whole genome sequencing in one case identified a TNFRSF1A gene variation linked to MS susceptibility.
- All patients received systemic steroids; azathioprine and rituximab were common immunomodulators.
- Good visual outcomes were observed in all cases at the last follow-up.
Conclusions:
- Multiple sclerosis (MS)-associated uveitis appears to be underdiagnosed and underreported in India.
- This case series provides valuable insights into the clinical spectrum of MS-associated uveitis in the Indian population.
- Further research is warranted to understand the prevalence and specific characteristics of MS-associated uveitis in India.
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