Cell-free chemoenzymatic cascades with bio-based molecules.

Area of Science:

• Green Chemistry
• Biocatalysis
• Catalysis

Background:

• Chemoenzymatic cascades offer high potential for valorizing bio-based feedstocks.
• Catalyst incompatibility currently limits the development of integrated chemoenzymatic systems.
• Advancing these systems is crucial for sustainable chemical synthesis.

Purpose of the Study:

• To review methods for developing chemoenzymatic cascades for bio-based feedstock upgrading.
• To highlight recent advances in combining enzymes with organo- and chemocatalysis.
• To explore future integration of photo- and electrocatalysis for novel synthetic routes.

Main Methods:

• Literature review of chemoenzymatic cascade development.
• Focus on enzyme integration with organo- and chemocatalysis.
• Analysis of emerging catalytic systems like photo- and electrocatalysis.

Main Results:

• Identified key methods to advance chemoenzymatic cascade development.
• Detailed recent progress in combining enzymes with traditional catalysis.
• Highlighted potential of novel catalytic systems for bio-based compound utilization.

Conclusions:

• Novel catalytic concepts are essential to overcome limitations in chemoenzymatic cascades.
• Integration of photo- and electrocatalysis opens new avenues for bio-based feedstock valorization.
• This review provides a roadmap for future research in sustainable chemical transformations.