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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
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RADIOPHARMACEUTICALS BASED ON FIBROBLAST ACTIVATION PROTEIN INHIBITORS IN ONCOLOGICAL PRACTICE
1Nonprofit Organization National Cancer Institute of Ministry of Health of Ukraine, 33/43 Julia Zdanovska Str., Kyiv, 03022, Ukraine.
Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii
|December 28, 2023
Summary
New fibroblast activation protein (FAP) inhibitors as radionuclide tracers show diagnostic efficacy in various cancers, comparable or superior to 18F-FDG PET/CT. These FAP inhibitors offer advantages for cancer diagnostics and therapy.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiopharmaceutical Chemistry
Background:
- Fibroblast activation protein (FAP) is a marker of cancer-associated fibroblasts in the tumor microenvironment.
- FAP inhibitors (FAPI) represent a novel class of radionuclide tracers with potential for both diagnosis and therapy.
- Current diagnostic methods like 18F-FDG PET/CT have limitations.
Purpose of the Study:
- To review the application of FAP inhibitors as radionuclide tracers in oncology.
- To evaluate the diagnostic efficacy of FAPI-based positron emission tomography/computed tomography (PET/CT) compared to existing methods.
- To explore the advantages of FAPI radiopharmaceuticals (RP) in cancer diagnostics.
Main Methods:
- Review of existing literature on FAP inhibitors and their application in radionuclide imaging.
- Comparison of diagnostic performance of FAPI PET/CT with 18F-fluorodeoxyglucose (FDG) PET/CT.
- Analysis of FAPI radiopharmaceuticals' characteristics and potential benefits.
Main Results:
- FAPI can be labeled with various radionuclides for diagnostic and therapeutic purposes.
- FAPI PET/CT demonstrates diagnostic efficacy similar to or superior to 18F-FDG PET/CT in diverse cancers.
- FAPI RP offer advantages over 18F-FDG, including no special preparation, fast imaging, high contrast, and increased sensitivity in certain metabolic regions.
Conclusions:
- FAPI PET/CT is a promising addition to conventional oncology diagnostics across all stages.
- FAPI PET/CT can be particularly valuable when 18F-FDG is unsuitable.
- Further prospective studies are needed to fully assess FAPI RP efficacy and establish clinical indications.
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