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Updated: Jul 6, 2025

Detection of Protein Ubiquitination Sites by Peptide Enrichment and Mass Spectrometry
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A Qualitative Method to Detect Paraproteins from Serum Using Ultra Performance Liquid Chromatography Electrospray

Deepalakshmi D Putchen1,2, Athira Nambiar1, Akshata R Gondkar3

  • 1R&D, Neuberg Anand Academy of Laboratory Medicine Pvt. Ltd., Bengaluru, India.

The Journal of Applied Laboratory Medicine
|December 29, 2023
PubMed
Summary

Ultra performance liquid chromatography electrospray ionization triple quadrupole mass spectrometry can identify paraprotein subtypes. This mass spectrometry method shows high agreement with immunofixation electrophoresis, aiding in detecting drug interference and biclonal paraproteins.

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