drCORRECT: An Algorithm for the Preventive Administration of Postprandial Corrective Insulin Boluses in Type 1...

In type 1 diabetes therapy, precise tuning of postprandial corrective insulin boluses (CIBs) is crucial to mitigate hyperglycemia without inducing dangerous hypoglycemic events. Several heuristic formulas accounting for continuous glucose monitoring (CGM) trend have been proposed in the literature. However, these formulas suggest a lot of quantized CIB adjustments, and they lack personalization.

drCORRECT algorithm proposed in this work employs a patient-specific time parameter and the "dynamic risk" (DR) measure to determine postprandial CIB suggestion. The expected benefits include the reduction of time in hyperglycemia, thanks to the preventive action exploited through DR. drCORRECT has been assessed retrospectively vs the literature methods proposed by Aleppo et al (AL), Bruttomesso et al (BR), and Ziegler et al (ZI) using a data set of 49 CGM daily traces recorded in free-living conditions. Retrospective evaluation of the algorithms is made possible by the use of ReplayBG, a digital twin-based tool that allows assessing alternative insulin therapies on already collected glucose data. Efficacy in terms of glucose control was measured by temporal, risk indicators, and dedicated hyperglycemic/hypoglycemic events metrics.

drCORRECT significantly reduces time spent in hyperglycemia when compared with AL and BR (33.52 [24.16, 39.89]% vs 39.76 [22.54, 48.15]% and 36.32 [26.91, 45.93]%, respectively); significantly reduces daily injected insulin (5.97 [3.80, 8.06] U vs 7.5 [5.21, 10.34] U), glycemia risk index (38.78 [26.58, 55.39] vs 40.78 [27.95, 70.30]), and time spent in hypoglycemia (0.00 [0.00, 1.74]% vs 0.00 [0.00, 10.23]%) when compared with ZI, resulting overall in a safer strategy.

The proposed drCORRECT algorithm allows preventive actions thanks to the personalized timing configuration and the introduction of the innovative DR-based CIB threshold, proving to be a valid alternative to the available heuristic literature methods.