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Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Multifunctional nanoparticle-mediated combining therapy for human diseases.

Xiaotong Li¹, Xiuju Peng¹, Makhloufi Zoulikha¹

¹School of Pharmacy, China Pharmaceutical University, Nanjing, 2111198, PR China.

Signal Transduction and Targeted Therapy

|December 31, 2023

Summary

Combination therapy using nanoparticle (NP)-mediated drug delivery enhances treatment for diseases like cancer. This approach offers targeted delivery, reduced toxicity, and overcomes drug resistance, paving the way for advanced therapeutic strategies.

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Area of Science:

Biomedical Engineering
Nanotechnology
Pharmacology

Background:

Combining existing drugs offers synergistic effects, reduced dosage, and decreased toxicity.
Combinatorial therapy targets multiple disease pathways, crucial for complex illnesses.
Nanoparticle (NP) drug delivery systems enhance stability, targeting, and release profiles.

Purpose of the Study:

To review disease targets, drug combinations, and NP-based delivery strategies for combinatorial therapy.
To emphasize NP-mediated combinatorial therapeutic strategies for severe clinical diseases.
To discuss challenges and potential solutions in developing NP co-delivery systems.

Main Methods:

Literature review of preclinical and clinical studies on drug combinations.
Analysis of various nanoparticle (NP) drug delivery systems (liposomal, polymeric, nanocrystals).
Examination of disease targets and therapeutic strategies utilizing NP-mediated co-delivery.

Main Results:

Nanoparticle drug delivery systems show promise for targeted delivery, extended release, and improved drug stability.
Combinatorial therapy using NPs is effective against various diseases including cancer, inflammatory, and neurodegenerative disorders.
Multifunctional NPs are being developed for enhanced combinatorial therapeutic efficacy.

Conclusions:

NP-mediated combinatorial therapy presents a promising strategy for treating severe human diseases.
Further research is needed to address challenges in NP co-delivery and clinical translation.
This review provides an overview of cutting-edge developments and challenges in NP-mediated combination therapy.