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H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer
Prerana R Chowdhury1, Shamala Salvamani1, Baskaran Gunasekaran2
1Division of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia.
The Yale Journal of Biology and Medicine
|January 1, 2024
Summary
The long non-coding RNA H19 is overexpressed in colorectal cancer (CRC), promoting tumor growth and metastasis. H19 serves as a valuable prognostic marker and potential therapeutic target for CRC.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Colorectal cancer (CRC) is a leading cause of cancer death globally.
- Increasing incidence of CRC is linked to chronic illness, age, and lifestyle factors.
- Novel biomarkers are crucial for improving CRC diagnosis and prognosis.
Purpose of the Study:
- To investigate the role of long non-coding RNA H19 in colorectal cancer.
- To evaluate H19 as a potential diagnostic and prognostic biomarker for CRC.
- To explore H19 as a therapeutic target in CRC treatment.
Main Methods:
- Analysis of H19 expression in tumor tissues.
- Investigation of H19's mechanisms in CRC cell growth, proliferation, invasion, and metastasis.
- Exploration of the H19-miRNA-mRNA ceRNA network.
Main Results:
- H19 is overexpressed in malignant CRC tissues compared to non-malignant tissues.
- H19 promotes CRC cell growth, proliferation, invasion, and metastasis.
- H19 functions as a miRNA sponge within the ceRNA network.
Conclusions:
- H19 is an independent prognostic marker for colorectal cancer.
- H19 overexpression is associated with poor prognosis in CRC patients.
- H19 represents a promising therapeutic target for CRC treatment.
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