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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Associations Between Resolvin D1 and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in Patients

Runzhen Chen1,2, Jiannan Li1,3, Zhaoxue Sheng4

  • 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Journal of Inflammation Research
|January 2, 2024
PubMed

Insights

High levels of resolvin D1 (RvD1) are linked to unstable coronary plaques in patients with ST-segment elevation myocardial infarction (STEMI). This suggests RvD1 may play a role in plaque rupture and calcification, indicating increased cardiovascular risk.

Area of Science:

  • Cardiovascular Research
  • Lipid Mediators
  • Atherosclerosis Pathophysiology

Background:

  • Resolvin D1 (RvD1) is a pro-resolving lipid mediator known to inhibit atherosclerosis by reducing oxidative stress and inflammation.
  • The specific role of RvD1 in human coronary artery disease, particularly in ST-segment elevation myocardial infarction (STEMI), remains largely uncharacterized.

Purpose of the Study:

  • To investigate the association between plasma levels of RvD1 and the characteristics of culprit plaques in patients diagnosed with STEMI.
  • To determine if RvD1 levels correlate with specific plaque morphologies indicative of instability.

Main Methods:

  • Analysis of 240 STEMI patients who underwent optical coherence tomography (OCT).
  • Quantification of plasma RvD1 levels using enzyme-linked immunosorbent assay (ELISA).
  • Application of logistic regression and receiver operating curve (ROC) analysis to assess associations and identify predictive thresholds.

Main Results:

  • The median plasma RvD1 level was 129.7 pg/mL.
  • Elevated RvD1 levels (≥111.5 pg/mL) were significantly associated with plaque rupture (OR: 2.09).
  • Higher RvD1 concentrations correlated with healed plaques (≥246.4 pg/mL, OR: 2.17) and calcification (≥293.38 pg/mL, OR: 2.10).

Conclusions:

  • Increased plasma RvD1 levels are associated with more unstable coronary atherosclerotic plaques in STEMI patients.
  • These findings suggest RvD1 may be a biomarker for plaque vulnerability and a potential therapeutic target in managing coronary artery disease.
Abstract

Keywords:
atherosclerosisinflammationmyocardial infarctionoptical coherence tomographyresolvin D1specialized pro-resolving lipid mediator

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