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Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
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Heterotopic Ossification and Platelet-Rich Plasma in Core Muscle Injuries: A Single-Institution Experience Over 6
Alexander E Poor1,2,3, Adam C Zoga2, Alec Warren1
1Vincera Institute, Philadelphia, Pennsylvania, USA.
The American Journal of Sports Medicine
|January 2, 2024
Summary
Platelet-rich plasma (PRP) therapy for core muscle injuries (CMIs) may be linked to heterotopic ossification (HO) in athletes. Further research confirms this association, highlighting potential risks of PRP treatment for sports-related groin injuries.
Area of Science:
- Orthopedic Surgery
- Sports Medicine
- Regenerative Medicine
Background:
- A prior study on platelet-rich plasma (PRP) for groin injuries in National Football League (NFL) players suggested a link to heterotopic ossification (HO).
- This study provides a more extensive analysis of this potential association in athletes treated between 2014 and 2019.
Purpose of the Study:
- To evaluate short-term clinical outcomes following groin surgery in athletes who previously underwent failed PRP therapy.
- To test the hypothesis that prior PRP treatment is associated with the development of HO in patients with core muscle injuries (CMIs).
Main Methods:
- A cohort study comparing athletes with CMIs who received PRP treatment versus those who did not.
- HO identification through clinical examination, imaging, intraoperative findings, and pathological confirmation.
- Successful surgery defined as return to pre-injury performance levels; PRP group followed for ≥2 years.
Main Results:
- Of 3642 patients with CMIs, 68 developed HO; 44 of these had prior PRP treatment.
- NFL players treated with PRP had a significantly higher incidence of HO (78.6%) compared to a matched control group (0%).
- Post-surgery, 3-month success rates were lower in the PRP group (67.9%) versus the non-PRP group (96.4%), with scar tissue contributing to delays.
Conclusions:
- This comprehensive study supports the preliminary finding that PRP treatment for CMIs may be associated with HO.
- The results suggest caution regarding the use of PRP for certain sports-related injuries due to the risk of HO development.
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