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Mechanics Of Ultrasonic Neuromodulation In A Mouse Subject.

Hossein Salahshoor1, Hongsun Guo2, Mikhail G Shapiro2

  • 1Division of Engineering and Applied Science, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125.

Extreme Mechanics Letters
|January 3, 2024
PubMed
Summary
This summary is machine-generated.

Focused ultrasound neuromodulation (UNM) may cause sensory effects due to complex wave patterns. The skull and spine influence wave propagation, impacting UNM

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Area of Science:

  • Neuroscience
  • Biophysics
  • Biomedical Engineering

Background:

  • Ultrasound neuromodulation (UNM) uses focused ultrasound (FUS) to modulate neural activity, showing promise for neuroscience research.
  • Understanding off-target sensory effects and their frequency dependence is crucial for safe and effective UNM application.

Purpose of the Study:

  • To investigate the off-target sensory effects of focused ultrasound neuromodulation (UNM).
  • To analyze the frequency-dependent response of biological tissues to FUS, particularly in mouse models.

Main Methods:

  • Developed a finite-element model of a mouse, incorporating elasticity and viscoelasticity.
  • Simulated the response of mouse models to focused ultrasound (FUS) to analyze pressure-wave patterns and tissue response.

Main Results:

  • Focused ultrasound (FUS) creates complex, delocalized pressure waves within the brain.
  • The cranium insulates the brain from shear waves, which are then guided by the vertebral column in a frequency-dependent manner.
  • Off-target skin locations experience attenuated displacements and stresses that could potentially elicit sensory responses.

Conclusions:

  • The skull and vertebral column significantly influence ultrasound wave propagation, affecting UNM.
  • Frequency-dependent wave mechanisms may contribute to observed frequency dependencies in UNM.
  • Potential for off-target sensory stimulation exists, necessitating careful consideration in UNM protocol design.