A Synthetic Route to Highly Substituted 1-Aminonaphthalenes from Readily Available Benzaldehydes
Hamza Enesi Ozomarisi1, Kellen T Sharpe1, Victor K Outlaw1
1Department of Chemistry, University of Missouri, Columbia, Missouri 65211, United States.
Abstract:
We report an efficient route for the synthesis of highly substituted 1-aminonaphthalenes from benzaldehydes. The method employs a stereoselective Still-Gennari modification of the Horner-Wadsworth-Emmons olefination to afford (E)-benzylidenesuccinonitrile precursors, which undergo Bronsted acid mediated benzannulation to afford 1-aminonaphthalene derivatives in 35-95% yield. The abundance of commercially available benzaldehydes, coupled with the simplicity of our method, enables many previously unexplored naphthalene substitution patterns to become readily accessible.
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