Photoacoustic image reconstruction with an objective function using TGV and ESTGV as a regularization functional
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Updated: Aug 30, 2026

High-Speed Ultraviolet Photoacoustic Microscopy for Histological Imaging with Virtual-Staining assisted by Deep Learning
Published on: April 28, 2022
Abstract:
Photoacoustic tomographic imaging is a non-invasive medical diagnostic technology for visualizing biological tissue. However, the inverse problem and noise in photoacoustic signals often cause blurred images. Existing regularization methods struggle with staircasing artifacts and edge preservation. To overcome this, an objective function incorporating total generalized variation (TGV) is proposed. However, it failed with high-density Gaussian noise. To address this, an extended version called edge-guided second-order TGV (ESTGV) is introduced. For sparsification, wavelet transform and discrete cosine transform are introduced, while the fast-composite-splitting algorithm is employed for the inverse problem solution. Experimental validation demonstrates the potential of these approaches.
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