Dissociation between adrenarche and gonadarche in two longstanding hypothyroid youngsters

An evident dissociation between adrenarche and gonadarche was found in two longstanding hypothyroid youngsters, one male and one female, with advanced gonadal development and absent sexual hair. This discrepancy rapidly vanished after the institution of thyroxine substitutive treatment. These case reports underline the important relationships existing between thyroid function and endocrine systems involved in the regulation of adrenarche and gonadarche.