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Lactate administration improves laboratory parameters in murine models of iron overload
Wei Liu1,2, Yue Wu2,3, Huaiqing Wei1,4
1Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Blood
|January 9, 2024
Abstract:
Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic iron levels in mouse models of iron overload with an improved erythropoiesis in β-thalassemic mice.
