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Deoxycholic Acid, a Secondary Bile Acid, Increases Cardiac Output and Blood Pressure in Rats
Artur Nowiński1, Dawid Chabowski1, Joanna Giebułtowicz2
1Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-106 Warsaw, Poland.
Nutrients
|January 11, 2024
Summary
Deoxycholic acid (DCA), a gut bacteria metabolite, increases blood pressure by boosting cardiac output. This suggests DCA may link gut microbiota to cardiovascular health.
Area of Science:
- Cardiovascular Physiology
- Microbiome Research
- Metabolomics
Background:
- Deoxycholic acid (DCA) is a secondary bile acid produced by gut bacteria.
- Elevated serum DCA concentrations are linked to cardiovascular disease (CVD).
Purpose of the Study:
- To investigate the influence of deoxycholic acid (DCA) on hemodynamic parameters in rats.
- To explore the potential role of DCA in the gut microbiota-host circulatory system interaction.
Main Methods:
- Systemic blood DCA concentration measured using liquid chromatography-mass spectrometry.
- Arterial blood pressure (BP), heart rate (HR), and echocardiographic parameters evaluated in anesthetized rats.
- Mesenteric artery (MA) reactivity assessed ex vivo.
Main Results:
- Intravenous DCA administration dose-dependently increased BP and HR, enhancing cardiac contractility and output.
- DCA induced relaxation of mesenteric arteries (MAs); systemic vascular resistance remained unchanged.
- Tested antagonists did not significantly alter the DCA-induced pressor effect; intracerebroventricular infusion showed no significant hemodynamic changes.
Conclusions:
- DCA elevates blood pressure primarily by augmenting cardiac output.
- DCA, as a gut microbiota metabolite, may mediate interactions between the gut microbiome and the host's circulatory system.
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