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Emerging epigenetic insights into aging mechanisms and interventions
Zeming Wu1, Weiqi Zhang2, Jing Qu3
1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
Trends in Pharmacological Sciences
|January 12, 2024
Summary
Epigenetic dysregulation is key to aging. Understanding DNA methylation, histone, RNA, and noncoding RNA modifications offers new ways to predict and treat age-related diseases.
Area of Science:
- Gerontology
- Epigenetics
- Molecular Biology
Background:
- Epigenetic dysregulation is a major driver of the aging process.
- The field of epigenetics provides crucial insights into aging mechanisms and potential therapies for age-related diseases.
- Recent advancements have significantly improved our understanding of the aging epigenome.
Purpose of the Study:
- To review recent discoveries in epigenetic mechanisms and targets for aging.
- To explore interventions and clinical trials for healthy aging.
- To discuss the impact of epigenetic factors on aging and related disorders.
Main Methods:
- Literature review of recent discoveries in epigenetics and aging.
- Analysis of epigenetic modifications including DNA methylation, histone modifications, RNA modifications, and noncoding RNAs.
- Examination of current and emerging interventions for healthy aging.
Main Results:
- Significant progress has been made in understanding the epigenetic landscape of aging.
- New epigenetic mechanisms and targets for predicting and intervening in aging have been identified.
- Emerging interventions and clinical trials show promise for promoting healthy aging.
Conclusions:
- Epigenetic modifications play a critical role in aging and age-related diseases.
- Targeting epigenetic pathways offers promising therapeutic strategies for healthy aging.
- Further research into epigenetic influences is essential for developing effective interventions.
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