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Type 1 diabetes, its complications, and non-ischemic cardiomyopathy: a mendelian randomization study of European

Yunyue Zhao1, Enxi Quan2, Tao Zeng3

  • 1Department of Cardiology, The Third Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

Cardiovascular Diabetology
|January 13, 2024
PubMed

Insights

Type 1 diabetes (T1D) causally increases the risk of non-ischemic cardiomyopathy (NICM). Monokine induced by gamma interferon may mediate this T1D-NICM link, offering potential therapeutic targets.

Area of Science:

  • Cardiovascular Disease Research
  • Endocrinology and Metabolism
  • Genetic Epidemiology

Background:

  • Type 1 diabetes (T1D) is a known risk factor for cardiovascular diseases.
  • The causal link and underlying mechanisms between T1D and non-ischemic cardiomyopathy (NICM) require further elucidation.

Purpose of the Study:

  • To investigate the causal effect of T1D and its complications on NICM development using Mendelian randomization.
  • To identify potential mediators in the pathway from T1D to NICM.

Main Methods:

  • Employed two-sample, multivariable, and mediation Mendelian randomization (MR) analyses.
  • Utilized genetic variants as instrumental variables for T1D, with data from genome-wide association studies and a Finnish database.
  • Adjusted for confounding factors like body mass index and hypertension.

Main Results:

  • Confirmed a significant causal association between T1D, T1D with complications, and NICM (ORs ranging from 1.02 to 1.03).
  • The causal link persisted even after adjusting for key confounding factors.
  • Mediation analysis suggested a potential role for monokine induced by gamma interferon in T1D-NICM pathogenesis (OR 1.005).

Conclusions:

  • Established a causal relationship between Type 1 diabetes and non-ischemic cardiomyopathy.
  • Identified monokine induced by gamma interferon as a potential mediator in the development of NICM in T1D patients.
Abstract

Keywords:
Mediation analysisMendelian randomizationNon-ischemic cardiomyopathyType 1 diabetesType 1 diabetes with complication

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