Related Experiment Video

Updated: Aug 10, 2026

Quantification of Coenzyme A in Cells and Tissues
08:51

Quantification of Coenzyme A in Cells and Tissues

Published on: September 27, 2019

Possible role for fatty acyl-coenzyme A in intracellular protein transport

B S Glick, J E Rothman

    Nature
    |March 19, 1987
    PubMed

    More Related Videos

    Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry07:27

    Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

    Published on: April 9, 2021

    Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs06:03

    Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs

    Published on: August 15, 2025

    Related Concept Videos

    Lipids as Anchors01:32

    Lipids as Anchors

    In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
    The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...
    The ADP/ATP Carrier Protein01:42

    The ADP/ATP Carrier Protein

    ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...
    Protein Transport into the Inner Mitochondrial Membrane01:34

    Protein Transport into the Inner Mitochondrial Membrane

    Nuclear encoded mitochondrial precursors are imported to the inner membrane in a multistep process involving two separate translocons, TIM22 and TIM23. TIM23 is a cation-selective pore that remains closed by the N terminal segment of the protein. Negative charges on the TIM23 act as a receptor for the incoming precursor, pulling the positively charged matrix-targeting sequence for peptide insertion and translocation.
    Transport of mitochondrial precursors across the TIM23 channel is driven by...
    COP Coated Vesicles00:59

    COP Coated Vesicles

    Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of different...
    Overview of Fatty Acid Metabolism01:28

    Overview of Fatty Acid Metabolism

    Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
    Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
    Protein Transport to the Thylakoids01:22

    Protein Transport to the Thylakoids

    Thylakoids are membrane-bound sac-like structures within the chloroplast that serve as sites for photosynthesis. Thylakoid lumen contains many electron transport proteins and is enclosed by a thylakoid membrane rich in the light-harvesting complex. Proteins targeted to the thylakoids are transported as precursors and are sorted by the general TOC/TIC import pathway. Once the precursor reaches the stroma, stromal processing peptidases remove their transit signal and expose thylakoid signal...