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Updated: Jul 5, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Secondary metabolites from Scindapsus officinalis (Roxb.) Schott. with in vitro antidiabetic activities
Lei Zhao1, Yan Wang1, Zhenqiang Wang2
1Chemical Technology Research Institute of Shandong, Qingdao University of Science and Technology, Jinan 250014, PR China.
Abstract:
One new phenolic cyclobutantetraol ester united chromone glycoside (1), one new amide (2), and three new phenyl ethanol glycosides (3-5) were obtained from the water extract of Scindapsus officinalis (Roxb.) Schott, in which compound 1 was the first reported structure incorporating the phenolic cyclobutantetraol ester and chromone via the glucose phenolic metabolites in nature. Structures of the isolated compounds, including absolute configurations, were elucidated according to the analysis of HRESIMS, NMR, ECD and BLYP/6-31G* geometry optimization calculations of 13C NMR data. All isolates (1-5) were evaluated for the antidiabetic activity by the insulin resistance (IR) model and anti-inflammatory activity against NO production in vitro. Compounds 1-3 showed strong antidiabetic activities, greatly promoting the glucose consumption in the insulin resistance HepG2 cells compared with the model group, however, 1-5 showed weak anti-inflammatory activities.
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