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Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

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Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
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Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

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Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
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Related Experiment Video

Updated: Jul 5, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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[A e-Hypercalcemia].

P Guillaud1, P Vest1, M Billhot2

  • 1Laboratoire de biologie-HIA Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France.

La Revue De Medecine Interne
|January 16, 2024
PubMed
Summary
This summary is machine-generated.

Vitamin D supplement intoxication can cause severe hypercalcemia. Healthcare providers must be aware of this rare but serious cause of poisoning to ensure prompt diagnosis and treatment.

Keywords:
Auto-médicationComplément alimentaireDietary supplementsHypercalcemiaHypercalcémieHypervitaminose DHypervitaminosis DSelf-medication

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Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
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Area of Science:

  • Endocrinology
  • Clinical Toxicology

Background:

  • Hypercalcemia is a common finding, primarily caused by hyperparathyroidism and malignancy.
  • Less common etiologies, such as poisoning, require careful consideration.

Observation:

  • An 82-year-old female presented with falls, confusion, and digestive issues, exhibiting severe hypercalcemia (>3 mmol/L).
  • Investigation revealed extremely high 25-hydroxyvitamin D levels, linked to an internet-purchased supplement prescribed by her dentist.

Findings:

  • The patient's symptoms were attributed to vitamin D toxicity from a dietary supplement.
  • This case highlights a rare but significant cause of hypercalcemia.

Implications:

  • Vitamin D supplement intoxication is a potentially serious condition.
  • Increased awareness among patients and healthcare professionals is crucial for prevention and early diagnosis.