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Cyanoacrylate Adhesives Used for Topical Hemostasis A Systematic Review

Alexandru Ilie-Ene, Victor Eşanu, Vlad Făgărăşan

    Chirurgia (Bucharest, Romania : 1990)
    |January 16, 2024
    PubMed

    Insights

    Cyanoacrylate adhesives (CA) show significant topical hemostatic properties, comparable to other effective materials. Further research into CA-based compounds is promising for developing ideal hemostatic agents.

    Area of Science:

    • Surgical Innovation
    • Biomaterials Science
    • Hemostasis Research

    Background:

    • Topical hemostatic agents are crucial in surgical and emergency settings.
    • Cyanoacrylate adhesives (CA) have demonstrated potential for topical hemostasis.
    • A comprehensive review of current evidence is needed.

    Purpose of the Study:

    • To systematically review the topical hemostatic properties of Cyanoacrylate Adhesives (CA).
    • To evaluate the efficacy and safety of CA as hemostatic agents.
    • To identify research gaps and future directions in CA-based hemostasis.

    Main Methods:

    • Systematic review of studies on topical hemostasis and CA.
    • Searched Embase, Scopus, PubMed, and Web of Science databases.
    • Included English articles from the last 10 years, encompassing reviews, meta-analyses, clinical trials, experimental studies, and case reports.
    • Assessed risk of bias using study-specific tools.

    Main Results:

    • A total of 42 studies were included in the review.
    • Cyanoacrylate adhesives demonstrated significant topical hemostatic capabilities.
    • CA's hemostatic performance was comparable to other effective hemostatic materials.
    • High heterogeneity among studies precluded a meta-analysis.

    Conclusions:

    • Cyanoacrylate adhesives are potent topical hemostatic agents.
    • CA-based compounds represent a key area for developing advanced hemostatic materials.
    • Further research is warranted to optimize CA for hemostatic applications.

    Keywords:
    cyanoacrylatehemostaticmaterialtissueadhesivetopicalhemostasis

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