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Updated: Jul 5, 2025
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In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
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Tumor-Associated Macrophages in Merkel Cell Carcinoma: Old Balances, New Checks
Ann W Silk1, Diwakar Davar2,3
1Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Abstract:
A recent report sheds light on the tumor-associated macrophages (TAM) in Merkel cell carcinoma (MCC), and the association of S100A8-expressing TAMs with resistance to anti-PD-(L)1 inhibitors. These data improve our understanding about why some tumors with brisk tumor-infiltrating lymphocytes do not respond to immunotherapy and provide a compelling rationale to target myeloid checkpoints in MCC. See related article by Tabachnick-Cherny et al., p. xxxx.
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