RELEVANCE FOR DIAGNOSIS, THERAPY, AND STRATEGIES OF GUT MICROBES DYSBIOSIS IN CHRONIC KIDNEY DISEASE: A SYSTEMATIC...

Area of Science:

• Microbiology
• Nephrology
• Gastroenterology

Background:

• Chronic Kidney Disease (CKD) is associated with gut dysbiosis and impaired gastrointestinal barrier function.
• Inflammation plays a crucial role in the pathophysiology of CKD, with gut microbiota influencing this process.
• Understanding the bidirectional relationship between CKD and gut microbiota is essential for developing new therapeutic strategies.

Approach:

• This systematic review followed the Preferred Reporting Items for Systematic reviews and Meta Analyses (PRISMA) guidelines.
• Data from human clinical trials and rat models were analyzed to explore the impact of CKD on gut microbiota.
• The review investigated diagnostic tools for gut microbiota abnormalities and targeted therapies for CKD.

Key Points:

• CKD is inversely associated with gut microbial dysbiosis, altering gut microbiota composition and function.
• Gut microbiota modifications in CKD can lead to gastrointestinal health issues and systemic inflammation.
• Therapeutic interventions targeting gut microbiota show promise in slowing CKD progression and managing complications.

Conclusions:

• Investigating the gut microbiota-CKD axis is critical for advancing therapeutic interventions.
• Targeting gut microbiota offers a promising avenue for improving patient outcomes and quality of life in CKD.
• Further research into gut microbiota modulation is essential for novel CKD management strategies.