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Related Experiment Video

Updated: Jul 5, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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Long Covid.

Asiya Kamber Zaidi1, Puya Dehgani-Mobaraki2

  • 1ENT Surgeon and Research Fellow, Associazione Naso Sano, Italy.

Progress in Molecular Biology and Translational Science
|January 18, 2024
PubMed
Summary
This summary is machine-generated.

Long COVID (post-acute sequelae of SARS-CoV-2 infection) involves persistent symptoms due to various factors like viral persistence and immune issues. Understanding its pathogenesis, risks, and manifestations is key for effective diagnosis and treatment.

Keywords:
Long CovidLong haulersPASCSARS-CoV-2 persistence

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Neurology

Background:

  • Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), presents persistent symptoms beyond the acute COVID-19 phase.
  • It affects multiple organ systems and presents a complex clinical challenge.

Purpose of the Study:

  • To provide a comprehensive overview of Long COVID.
  • To explore its pathogenesis, risk factors, clinical manifestations, and diagnostic and therapeutic strategies.

Main Methods:

  • Review of current hypotheses on Long COVID pathogenesis.
  • Analysis of risk factors, including pediatric cases.
  • Exploration of major clinical findings across various systems.
  • Discussion of diagnostic challenges and treatment approaches.

Main Results:

  • Pathogenesis theories include viral reservoirs, immune dysregulation (including herpesvirus reactivation), dysbiosis, autoimmunity, and endothelial dysfunction.
  • Key manifestations involve neurological, cognitive, respiratory, gastrointestinal, and reproductive systems, alongside immune, vascular, and endocrine changes.
  • Risk factors and pediatric occurrences are also detailed.

Conclusions:

  • Long COVID is a multifaceted condition with diverse potential causes and widespread effects.
  • Effective management requires multidisciplinary care and individualized treatment strategies tailored to patient needs.