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Motion-resistant three-wavelength spatial frequency domain imaging system with ambient light suppression using an

Yu Feng1, Chen Cao2, Yuto Shimada1

  • 1Shizuoka University, Graduate School of Integrated Science and Technology, Hamamatsu, Japan.

Journal of Biomedical Optics
|January 19, 2024
PubMed
Summary

A new three-wavelength spatial frequency domain imaging (SFDI) system uses an 8-tap image sensor to reduce motion artifacts and ambient light. This innovation enables more reliable optical imaging in real-world conditions.

Keywords:
diffuse opticsmulti-tap complementary metal-oxide semiconductor image sensormultispectral imagingspatial frequency domain imaging

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Area of Science:

  • Biophotonics
  • Optical Imaging
  • Medical Diagnostics

Background:

  • Conventional spatial frequency domain imaging (SFDI) systems face limitations in motion resistance and ambient light suppression.
  • Real-world imaging conditions often introduce artifacts that compromise data reliability.

Purpose of the Study:

  • To develop and evaluate a motion-resistant, three-wavelength SFDI system with ambient light suppression.
  • To mitigate motion artifacts and ambient light bias in SFDI measurements.

Main Methods:

  • Utilized an 8-tap complementary metal-oxide semiconductor (CMOS) image sensor (CIS) for simultaneous multi-exposure image acquisition.
  • Implemented the Hilbert transform to reduce projected patterns per wavelength.
  • Employed ambient light subtraction and rapid exposure/projection for motion artifact suppression.

Main Results:

  • The 8-tap CIS-based SFDI system achieved an acquisition rate of 9.4 frame sets per second.
  • Demonstrated good agreement in diffuse reflectance maps with conventional SFDI for tissue phantoms.
  • Successfully measured hemoglobin concentration and oxygen saturation in vivo during motion and ambient light, with reduced artifacts.

Conclusions:

  • The developed 8-tap CIS-based SFDI system shows significant potential for motion-resistant, ambient light-suppressed optical imaging.
  • This system enhances the reliability of SFDI for challenging, real-world applications.