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Covalent-organic framework nanobionics for robust cytoprotection.

Jieying Liang1, Qianfan Chen2, Joel Yong1

  • 1School of Chemical Engineering and Australian Centre for NanoMedicine, The University of New South Wales Sydney NSW 2052 Australia jieying.liang@unsw.edu.au kang.liang@unsw.edu.au.

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|January 19, 2024
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Summary
This summary is machine-generated.

We developed a durable covalent-organic framework (COF) nanocoating for living cells. This robust coating protects cells from extreme conditions and enhances their use in challenging environments.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Covalent-organic frameworks (COFs) offer tunable properties for advanced applications.
  • Protecting living cells from environmental stressors is crucial for biotechnology.
  • Existing nanomaterials often lack the robustness needed for extreme conditions.

Purpose of the Study:

  • To develop and characterize a novel, in situ formed COF nanocoating on living cells.
  • To evaluate the nanocoating's protective capabilities against various lethal stressors.
  • To explore the potential of enzyme-functionalized COF nanocoatings for enhanced microbial function.

Main Methods:

  • In situ synthesis of COF nanocoating on yeast cells.
  • Exposure of coated cells to stressors: high temperature, extreme pH, UV radiation, metal ions, organic pollutants, oxidative stress.
  • Assessment of cell viability and metabolic activity (fermentation, ethanol production).

Main Results:

  • The COF nanocoating demonstrated exceptional durability and resistance to a wide array of lethal stressors.
  • Significant enhancement in cell survival was observed under high temperature and acidic conditions.
  • Enzyme-functionalized COF nanocoatings enabled yeast fermentation and ethanol production under strong oxidative stress.

Conclusions:

  • Durable COF nanocoatings provide a robust platform for protecting living cells.
  • This technology enables microbial utilization in previously inaccessible harsh environments.
  • COF nanocoatings represent a promising advancement in cell protection and bioengineering.