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Multimorbidity of Psoriasis: A Large-Scale Population Study of Its Associated Comorbidities
Manuel Almenara-Blasco1, Tamara Gracia-Cazaña1, Beatriz Poblador-Plou2,3
1Department of Dermatology, Miguel Servet University Hospital, IIS Aragon, Paseo Isabel la Católica 1-3, 50009 Zaragoza, Spain.
Introduction:
Psoriasis is a chronic disease of the skin with a prevalence of 2% in the general population. The high prevalence of psoriasis has prompted the study of its comorbidities in recent decades. We designed a study to determine the prevalence of psoriasis in a large-scale, population-based cohort, to exhaustively describe its comorbidities, and to analyze which diseases are associated with psoriasis.
Methods:
Retrospective, observational study based on the clinical information contained in the electronic health records of the individuals in the EpiChron Cohort with a diagnosis of psoriasis (31,178 individuals) in 2019. We used logistic regression models and calculated the likelihood of the occurrence of each comorbidity based on the presence of psoriasis (p-value < 0.05).
Results:
The prevalence of psoriasis was 2.84%, and it was more prevalent in men (3.31% vs. 2.43%). The most frequent chronic comorbidities were disorders of lipid metabolism (35.87%), hypertension (35.50%), and other nutritional-endocrine-metabolic disorders (21.79%). The conditions most associated with psoriasis were (odds ratio; 95% confidence interval) tuberculosis (2.36; 1.24-4.49), cystic fibrosis (2.15; 1.25-3.69), amongst others. We did not find a significant association between psoriasis and hypertension or neoplasms (0.90; 0.86-0.95).
Conclusions:
This study revealed significant associations between psoriasis and cardiac, psychological, and musculoskeletal comorbidities.
