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Sensitive and error-tolerant annotation of protein-coding DNA with BATH

Genevieve R Krause1,2, Walt Shands2,3, Travis J Wheeler1,2

  • 1R. Ken Coit College of Pharmacy, University of Arizona, Tucson, Arizona, USA.

Biorxiv : the Preprint Server for Biology
|January 23, 2024
PubMed
Summary

We developed BATH, a tool for sensitive protein-coding DNA annotation using profile hidden Markov models (pHMMs). It accurately detects frameshift indels, outperforming other tools for error-containing sequences.

Keywords:
Frameshift MutationsGenome AnnotationProfile Hidden Markov ModelsSequence Alignment

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