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Nanomaterials for light-mediated therapeutics in deep tissue
1Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117583, Singapore. e0974156@u.nus.edu.
Chemical Society Reviews
|January 24, 2024
Summary
New nanosystems enable deep tissue light-mediated therapies using near-infrared light, ultrasound, or X-rays. These advanced approaches overcome the limitations of UV and visible light, improving therapeutic efficacy in deeper tissues.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Photomedicine
Background:
- Light-mediated therapies offer high specificity but are limited by poor tissue penetration of UV/visible light.
- Nanosystems are being engineered to overcome these limitations by utilizing alternative excitation sources.
Purpose of the Study:
- To review the design and mechanisms of luminescent nanosystems activated by near-infrared (NIR) light, ultrasound, or X-ray.
- To explore methods for enhancing luminescence from these nanosystems.
- To highlight recent applications in deep tissue light-mediated therapeutics.
Main Methods:
- Systematic review of literature on luminescent nanosystems.
- Analysis of excitation mechanisms (NIR, ultrasound, X-ray, chemiluminescence).
- Evaluation of luminescence enhancement strategies and deep tissue therapeutic applications.
Main Results:
- Nanosystems can generate luminescence via NIR, ultrasound, X-ray, or chemiluminescence, enabling deeper tissue penetration.
- Various strategies exist to enhance the luminescence output of these nanosystems.
- These advanced systems show promise for effective deep tissue light-mediated therapies.
Conclusions:
- Alternative excitation sources and luminescent nanosystems significantly advance deep tissue light-mediated therapeutics.
- Further development in nanosystem design and luminescence enhancement is crucial for clinical translation.
- These technologies hold potential for treating deeper localized diseases with improved specificity.
