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Patients' Preferences for Systemic Lupus Erythematosus Treatments-A Discrete Choice Experiment
Hannah Collacott1, Andrea Phillips-Beyer2, Nicolas Krucien3
1Evidera, London, UK. hannah.collacott@evidera.com.
The Patient
|January 25, 2024
Summary
Systemic lupus erythematosus (SLE) patients have distinct treatment preferences. Benefit-seekers prioritize symptom relief, while risk-avoiders focus on avoiding side effects, highlighting personalized care needs.
Area of Science:
- Rheumatology
- Patient-reported outcomes
- Health economics
Background:
- Systemic lupus erythematosus (SLE) presents with diverse symptoms, including joint pain, rashes, and fatigue, impacting patient quality of life.
- Available SLE treatments offer variable efficacy but often carry significant side effects, particularly corticosteroids.
- Patient preferences regarding SLE treatment attributes remain largely unexplored.
Purpose of the Study:
- To identify key attributes influencing treatment choices for patients with moderate-to-severe SLE.
- To quantify the relative importance of these attributes in patient decision-making.
Main Methods:
- An online discrete choice experiment (DCE) involving adult SLE patients.
- Latent class modeling (LCL) to analyze patient choices between hypothetical treatments.
- Calculation of relative attribute importance (RAI) to rank treatment factors.
Main Results:
- Two distinct patient preference classes were identified: benefit-seekers and risk-avoiders.
- Benefit-seekers prioritized symptom reduction (joint pain, non-joint pain, fatigue, rashes/itching).
- Risk-avoiders prioritized avoiding corticosteroid side effects and infection risks, often with longer disease duration and prior corticosteroid use.
Conclusions:
- SLE patient preferences diverge into symptom-focused (benefit-seekers) and risk-averse (risk-avoiders) groups.
- These differences may stem from disease impact and treatment experience, influencing willingness to accept treatment risks.
- Personalized treatment strategies accounting for these distinct preferences are crucial for effective SLE management.
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