Polysaccharide mediated nanodrug delivery: A review

Area of Science:

• Biomaterials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Polysaccharides are natural macromolecules increasingly used as polymers in drug delivery systems.
• Their application in nanoparticle development aims to enhance therapeutic outcomes and minimize adverse effects.

Purpose of the Study:

• To provide an overview of challenges and detailed information on polysaccharides engineered into nanoparticles.
• To explore the diverse applications and potential of natural macromolecules as drug carriers.
• To assess the utilization and comprehension of polysaccharides in nanoapplications for therapeutics and industry.

Main Methods:

• Review of existing literature on polysaccharide-based nanoparticles for drug delivery.
• Detailed analysis of specific polysaccharides: Bael Fruit Gum, Guar Gum, Pectin, Agar, Cellulose, Alginate, Chitin, and Gum Acacia.
• Evaluation of their unique properties and strategic integration into nanoparticle formulations.

Main Results:

• Identified key polysaccharides with distinct properties suitable for nanoparticle engineering.
• Highlighted the potential of these natural macromolecules as effective carriers in drug delivery systems.
• Provided insights into the challenges and advancements in utilizing polysaccharides for nanomedicine.

Conclusions:

• Polysaccharides show significant promise as versatile carriers in advanced drug delivery systems.
• Further integration of these materials in nanomedicine and pharmaceutical technologies is supported.
• Continued research is crucial for optimizing polysaccharide-based nanoparticles in therapeutics and industrial applications.