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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Atypical Fibroxanthoma/Pleomorphic Dermal Sarcoma With Osseous Metaplasia: A Series of Three Cases.

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Related Experiment Video

Updated: Jul 4, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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Pleomorphic Dermal Sarcoma.

Jasmine S Saleh1, Carli P Whittington1, Scott C Bresler1

  • 1Department of Pathology, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.

Surgical Pathology Clinics
|January 26, 2024
PubMed
Summary
This summary is machine-generated.

Pleomorphic dermal sarcoma (PDS) is a rare skin cancer with aggressive features. Early recognition and management are crucial for better patient outcomes in treating this mesenchymal neoplasm.

Keywords:
Atypical fibroxanthomaMalignant fibrous histiocytomaPleomorphic dermal sarcomaSarcomaUndifferentiated pleomorphic sarcoma

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Pleomorphic dermal sarcoma (PDS) is a rare mesenchymal neoplasm.
  • It shares features with atypical fibroxanthoma (AFX) but is more aggressive.
  • PDS demonstrates deeper invasion and higher metastatic potential than AFX.

Purpose of the Study:

  • To review the clinicopathologic features of PDS.
  • To discuss the molecular aspects of PDS.
  • To outline the prognosis and treatment strategies for PDS.

Main Methods:

  • Literature review of PDS cases.
  • Analysis of histopathologic and immunohistochemical findings.
  • Review of clinical outcomes and treatment responses.

Main Results:

  • PDS is characterized by deeper tissue invasion compared to AFX.
  • PDS has a higher propensity for metastasis and local recurrence.
  • Distinct molecular markers may differentiate PDS from AFX.

Conclusions:

  • PDS requires prompt diagnosis and aggressive management due to its aggressive nature.
  • Understanding PDS clinicopathologic and molecular features is key for effective treatment.
  • Multidisciplinary approach is essential for optimizing patient outcomes in PDS.