Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does insulin bolster antioxidant defenses via the extracellular signal-regulated kinases-protein kinase B-nuclear factor erythroid 2 p45-related factor 2 pathway?

Antioxidants & redox signaling·2011
Same author

Decrease in calcium-sensing receptor in the progress of diabetic cardiomyopathy.

Diabetes research and clinical practice·2011
Same author

JAMIE: A software tool for jointly analyzing multiple ChIP-chip experiments.

Methods in molecular biology (Clifton, N.J.)·2011
Same author

Morphine-induced conditioned place preference in mice: metabolomic profiling of brain tissue to find "molecular switch" of drug abuse by gas chromatography/mass spectrometry.

Analytica chimica acta·2011
Same author

[The interventions effect-assessment of the workers exposed to N, N-dimethylformamide by percutaneous in a synthetic leather factory].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2011
Same author

[The analysis of effect of Th1/Th2 cytokine in the different prognosis in severe influenza A (H1N1)].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology·2011
Same journal

Molecular Pathology in Contemporary Surgical Practice.

Surgical pathology clinics·2026
Same journal

Beyond Blood: Liquid biopsy assays for nonplasma body fluids.

Surgical pathology clinics·2026
Same journal

The Molecular Landscape of Ovarian Neoplasms: A Review.

Surgical pathology clinics·2026
Same journal

Clinically Relevant Molecular Pathology of Endometrial Cancer.

Surgical pathology clinics·2026
Same journal

Molecular Pathology of Genitourinary Tumors: Diagnostic, Prognostic, and Therapeutic Implications.

Surgical pathology clinics·2026
Same journal

Oncogenicity and Therapeutic Implications of Molecular Biomarkers in Colorectal Carcinoma.

Surgical pathology clinics·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

1.9K

Myxoinflammatory Fibroblastic Sarcoma.

Hao Wu1, William B Laskin1

  • 1Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.

Surgical Pathology Clinics
|January 26, 2024
PubMed
Summary
This summary is machine-generated.

Myxofibrosarcoma (MIFS) is a low-grade soft tissue sarcoma typically found in extremities. While conventional MIFS has low metastatic risk, high-grade features increase recurrence and metastasis potential, necessitating wide local excision.

Keywords:
EmperipolesisMyxoinflammatory fibroblastic sarcomaPseudolipoblastsReed-Sternberg-like cellsVirocyte-like cells

More Related Videos

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

2.3K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.0K

Related Experiment Videos

Last Updated: Jul 4, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

1.9K
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

2.3K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.0K

Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Myxofibrosarcoma (MIFS) is a distinct low-grade fibroblastic sarcoma.
  • It characteristically affects superficial soft tissues of the distal extremities.
  • Histological features include plump spindled and epithelioid cells, inflammatory infiltrates, mucin deposits, and a fibrosclerotic stroma.

Purpose of the Study:

  • To describe the key histological characteristics of Myxofibrosarcoma.
  • To differentiate between conventional and high-grade MIFS.
  • To outline the recommended treatment and prognostic implications based on grade.

Main Methods:

  • Histopathological examination of tumor samples.
  • Analysis of cellular morphology, including nuclei, nucleoli, and pseudolipoblasts.
  • Correlation of histological grade with clinical outcomes (recurrence and metastasis).

Main Results:

  • Characteristic features include plump spindled/epithelioid cells, inflammatory infiltrates, mucin, and fibrosclerotic stroma.
  • Bizarre nuclei, virocyte-like macronucleoli, and pleomorphic pseudolipoblasts are notable.
  • High-grade histological features are associated with increased risk of recurrence and metastasis.

Conclusions:

  • Myxofibrosarcoma is a low-grade sarcoma with specific histological markers.
  • Histological grading is crucial for predicting clinical behavior.
  • Wide local excision is the recommended therapeutic approach for MIFS.