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Atypical Spindle Cell/Pleomorphic Lipomatous Tumor.
1Pathology, University of California, 1825 4th Street, Room M2369, Box 4066, San Francisco, CA 94158-4066, USA.
Surgical Pathology Clinics
|January 26, 2024
Summary
Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare, benign soft tissue neoplasm. While locally recurrent in 10-15% of cases, ASCPLTs do not metastasize or dedifferentiate.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare soft tissue neoplasm.
- It commonly arises in the subcutis of limbs and limb girdles in mid-adulthood.
- Histologically, ASCPLT is a lipogenic neoplasm with ill-defined margins, featuring spindle to pleomorphic/multinucleated cells in a fibromyxoid stroma.
Purpose of the Study:
- To characterize the histological and genetic features of ASCPLT.
- To differentiate ASCPLT from other lipomatous neoplasms.
- To clarify the clinical behavior and prognosis of ASCPLT.
Main Methods:
- Histopathological examination of ASCPLT specimens.
- Immunohistochemical analysis for markers such as CD34.
- Genetic analysis to assess for MDM2 amplification and RB1 deletion.
Main Results:
- ASCPLTs lack MDM2 amplification.
- A significant subset of ASCPLTs exhibit RB1 deletion.
- Variable CD34 expression is noted in ASCPLTs.
- The tumors are benign, with local recurrence rates of approximately 10-15% and no documented dedifferentiation or metastasis.
Conclusions:
- ASCPLT is a distinct benign lipomatous neoplasm.
- Genetic alterations, including RB1 deletion, are characteristic of ASCPLT.
- Despite a potential for local recurrence, ASCPLT has a favorable prognosis with no metastatic potential.
