Related Experiment Video
Updated: Jul 4, 2025

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
Published on: May 17, 2024
Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats
Ismail Bouadid1, Adil Qabouche1, Mohamed Eddouks1
1Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, Errachidia, BP 509, Boutalamine, Errachidia, Morocco.
Aims:
The antihypertensive activity of Daphne gnidium was tested.
Background:
Daphne gnidium (Thymelaeaceae) is used against hypertension.
Objective:
The antihypertensive effect of Daphne gnidium was evaluated in this study.
Methods:
The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.
Results:
DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.
Conclusion:
The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry.
Related Concept Videos
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Drugs: Vasodilators
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antihypertensive Drugs: Direct Renin Inhibitors
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Action of Diuretics

