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Implementation of a Reference Interferometer for Nanodetection

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Label-Free Biochemical Sensing Using Processed Optical Fiber Interferometry: A Review.

Rajan Jha¹, Pintu Gorai¹, Anand Shrivastav²

¹Nanophotonics and Plasmonics Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar, Odisha 752050, India.

|January 29, 2024

Summary

This summary is machine-generated.

Optical fiber interferometry biosensors offer compact, label-free detection for various applications. This review covers their fundamentals, advances, and commercialization prospects.

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Area of Science:

Biomedical Engineering
Optoelectronics
Chemical Sensing

Background:

Optical fiber devices are crucial for biochemical sensing in health, environment, and industry.
Effective functionalization with recognition agents is key for selective biochemical detection.
Optical fiber interferometry biosensors offer biocompatibility, sensitivity, and low detection limits.

Purpose of the Study:

To provide a comprehensive review of optical fiber interferometry-based biochemical sensors.
To discuss the fundamentals, current advances, and various interferometry techniques.
To explore challenges and solutions for commercializing these sensors.

Main Methods:

Review of Mach-Zehnder, Michelson, Fabry-Perot, Sagnac interferometers, and biolayer interferometry.
Comparative analysis of technical reports, including advantages and disadvantages.
Discussion of limitations and potential solutions for industrial applications.

Main Results:

Detailed overview of different optical fiber interferometry configurations.
Tabulated comparison of sensor technologies for clarity.
Identification of key challenges hindering commercialization.

Conclusions:

Optical fiber interferometry biosensors show significant promise for diverse applications.
Addressing current limitations is crucial for transitioning from lab to industry.
Future development focuses on commercialization and real-world problem-solving.