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Nature-Inspired Wet Drug Delivery Platforms
Yutian Ma1, Jian Cao2, Shiyao Li3
1Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Small Methods
|January 29, 2024
Summary
Nature inspires advanced wet adhesives for targeted drug delivery. Bioinspired materials mimic organisms, overcoming challenges in wet environments for better adhesion and controlled release on biological surfaces.
Area of Science:
- Biomimetics
- Materials Science
- Drug Delivery
Background:
- Organisms utilize unique structures for wet adhesion in diverse environments.
- Existing wet adhesives face challenges with tissue adhesion in biological fluids.
- Bioinspiration offers solutions for enhanced wet adhesion and controlled release.
Purpose of the Study:
- To review research progress in wet adhesion and bioinspired fabrication.
- To explore various natural adhesion mechanisms and their biomimetic potential.
- To highlight bioinspired wet adhesives as drug delivery platforms.
Main Methods:
- Review of different wet adhesion mechanisms (protein-based, capillarity, suction, friction).
- Analysis of bioinspired fabrication strategies.
- Examination of organism examples (mussels, frogs, octopuses, mayfly larvae).
Main Results:
- Diverse natural adhesion strategies offer design principles for synthetic adhesives.
- Bioinspired adhesives demonstrate enhanced wet adhesion on biological surfaces.
- These adhesives show promise as drug delivery systems with controlled release.
Conclusions:
- Bioinspired wet adhesives can overcome limitations of current technologies.
- Further research is needed to address challenges in developing these platforms.
- Optimized wet adhesion and drug release are key for future applications.
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