Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and
Seyed Alireza Dastgheib1, Soheila Sayad2, Sepideh Azizi3
1Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Asian Pacific Journal of Cancer Prevention : APJCP
|January 29, 2024
Summary
The Arg188His polymorphism in X-ray repair cross-complementing 2 (XRCC2) gene shows a marginal association with global breast cancer susceptibility. This genetic variation may increase breast cancer risk, particularly in Caucasian populations.
Area of Science:
- Oncology
- Genetics
- Molecular Epidemiology
Background:
- Breast cancer is a leading cause of cancer-related death in women globally.
- The association between the X-ray repair cross-complementing 2 (XRCC2) Arg188His polymorphism (rs3218536) and breast cancer risk is currently ambiguous.
- Clarifying this association is crucial for understanding genetic predispositions to breast cancer.
Approach:
- A comprehensive meta-analysis was conducted, systematically searching PubMed, Google Scholar, and ISI Web of Science.
- Seventeen studies comprising 5694 breast cancer cases and 6450 healthy controls were included.
- Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the strength of the association.
Key Points:
- The pooled analysis indicated a marginal association between the XRCC2 Arg188His polymorphism and breast cancer susceptibility globally (OR=0.929, 95% CI=0.873-0.987).
- Subgroup analysis by ethnicity revealed a significant association among Caucasian populations.
- The heterozygote contrast model showed a statistically significant result (p=0.018).
Conclusions:
- The XRCC2 Arg188His polymorphism may contribute to an increased risk of developing breast cancer.
- Further research is warranted to fully elucidate the role of XRCC2 polymorphisms in breast cancer etiology.
- Genetic variations in DNA repair genes like XRCC2 are important factors in cancer risk assessment.
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