Related Experiment Video
Updated: Jun 16, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
Pituitary hypophysitis in granulomatosis with polyangiitis (GPA): a case series
Majid Alameri1, Abdulla Alnuaimi1, Niamh M Martin1
1Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
Abstract:
Granulomatosis with polyangiitis (GPA) rarely involves the pituitary gland. Pituitary involvement has been reported in ~ 1% of all cases of GPA. Most commonly, pituitary swelling and inflammation results in symptoms due to pituitary mass effect and arginine vasopressin deficiency. To date, there are no pituitary-specific treatment guidelines for this rare condition. We present three patients with GPA-related hypophysitis highlighting the spectrum of pituitary involvement. All three patients were successfully treated with immunosuppressive regimens that included rituximab (RTX). Following remission induction with high-dose glucocorticoids, patients received 6 monthly RTX for remission maintenance. RTX was well tolerated without significant side effects.
Related Concept Videos
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Acute Pyelonephritis II: Diagnostic Studies and Management
Graves' Disease I: Introduction
Graves Disease II: Pathophysiology

