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Related Experiment Video

Updated: Jul 4, 2025

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
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Lipolytic agents for submental fat reduction: Review.

Soo Yeon Park1, Soo-Bin Kim2, Jovian Wan3

  • 1Made-Young Plastic Surgery Clinic, Seoul, South Korea.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|February 1, 2024
PubMed
Summary

This review examines lipolytic agents for submental fat reduction. It details agents like deoxycholic acid and aminophylline, discussing their mechanisms and applications in cosmetic procedures.

Keywords:
aesthetic proceduresanatomical considerationslipolytic agentssubmental fat reduction

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Area of Science:

  • Plastic Surgery and Dermatology
  • Aesthetic Medicine

Background:

  • Submental fat significantly impacts the aging appearance of the neck.
  • Youthful neck aesthetics are influenced by fat distribution, particularly in the submental region.

Purpose of the Study:

  • To comprehensively analyze various lipolytic agents for submental fat reduction.
  • To discuss the mechanisms, applications, and safety considerations of these agents in plastic surgery and dermatology.

Main Methods:

  • Review of lipolytic agents including aminophylline, hypotonic pharmacologic lipo-dissolution, lipolytic lymphatic drainage with hyaluronidase, glycerophosphorylcholine, and deoxycholic acid.
  • Analysis of their mechanisms of action, such as fat breakdown and metabolism activation.
  • Consideration of FDA approval status and safety concerns, including off-label use.

Main Results:

  • Aminophylline facilitates fat breakdown via increased cyclic adenosine monophosphate.
  • Deoxycholic acid is FDA-approved for submental fat reduction, though its precise mechanisms require further understanding.
  • Some agents like phosphatidylcholine with deoxycholate lack cosmetic approval due to safety issues.

Conclusions:

  • Understanding the complex anatomy and mechanisms of lipolytic agents is crucial for safe and effective submental fat reduction.
  • Evolving practices and off-label utilization necessitate adherence to clinical guidelines for safer applications.