Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Recrystallization: Solid–Solution Equilibria01:10

Recrystallization: Solid–Solution Equilibria

1.1K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
1.1K
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

1.9K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
1.9K
Precipitation Processes01:12

Precipitation Processes

451
The experimental conditions in a gravimetric analysis should be optimized to maximize the particle size and purity of the obtained precipitate. Ideally, the concentration of the precipitating reagent should be low with effective stirring to maintain low relative supersaturation for the growth of large crystals. In homogeneous precipitation, the precipitant is slowly generated by a chemical reaction in the solution to avoid local reagent excesses. For example, urea decomposes gradually to...
451
Colloidal precipitates01:09

Colloidal precipitates

582
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
582
High-Performance Liquid Chromatography: Introduction01:11

High-Performance Liquid Chromatography: Introduction

2.0K
High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:
2.0K
Distillation: Vapor–Liquid Equilibria01:01

Distillation: Vapor–Liquid Equilibria

2.8K
Distillation is a separation technique that takes advantage of the boiling point properties of disparate elements in a mixture. To perform distillation, we begin by heating a miscible mixture of two liquids with a significant difference in boiling points (at least 20°C). As the solution heats up and reaches the bubble point of the more volatile component, some molecules of the more volatile component transition into the gas phase and travel upward into the condenser, which is a glass tube...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of compound Yindan decoction on alpha-naphthylisothiocyanate-Induced acute intrahepatic cholestasis in rats.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2020
Same author

Amphiphilic Block Copolymers: A Novel Substance for Bitter-Masking in Aqueous Solutions.

Molecular pharmaceutics·2020
Same author

Extracellular Vesicle lncRNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Released From Glioma Stem Cells Modulates the Inflammatory Response of Microglia After Lipopolysaccharide Stimulation Through Regulating miR-129-5p/High Mobility Group Box-1 Protein Axis.

Frontiers in immunology·2020
Same author

Assembling PVP-Au NPs as portable chip for sensitive detection of cyanide with surface-enhanced Raman spectroscopy.

Analytical and bioanalytical chemistry·2020
Same author

Site-specific proteolytic cleavage prevents ubiquitination and degradation of human REV3L, the catalytic subunit of DNA polymerase ζ.

Nucleic acids research·2020
Same author

High level of circulating microRNA-142 is associated with acute myocardial infarction and reduced survival.

Irish journal of medical science·2020
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
Same journal

A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

Journal of pharmaceutical sciences·2026
Same journal

Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

Journal of pharmaceutical sciences·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2025

Crystallization of Membrane Proteins in Lipidic Mesophases
11:53

Crystallization of Membrane Proteins in Lipidic Mesophases

Published on: March 28, 2011

31.4K

Spherical Crystallization Based on Liquid-Liquid Phase Separation in a Reverse Antisolvent Crystallization Process.

Weizhong Gong1, Pan Li2, Sohrab Rohani3

  • 1Department of Chemical and Biochemical Engineering, Western University, London, ON, N6A 5B9, Canada; Department of Process Development, Wanhua Chemical Group Co., Ltd, Yantai, Shandong, 264006, China.

Journal of Pharmaceutical Sciences
|February 4, 2024
PubMed
Summary
This summary is machine-generated.

Spherical crystallization technology improves vanillin crystal properties. This study used reverse antisolvent crystallization to create spherical vanillin agglomerates with enhanced flowability and stability.

Keywords:
Hansen solubility parametersImproved morphologyLiquid-liquid phase separationSpherical crystallizationVanillin

More Related Videos

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
06:16

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

13.9K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

5.5K

Related Experiment Videos

Last Updated: Jul 4, 2025

Crystallization of Membrane Proteins in Lipidic Mesophases
11:53

Crystallization of Membrane Proteins in Lipidic Mesophases

Published on: March 28, 2011

31.4K
Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
06:16

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

13.9K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

5.5K

Area of Science:

  • Chemical Engineering
  • Crystallization Science

Background:

  • Needle-like vanillin crystals exhibit poor flowability, leading to processing challenges.
  • Spherical crystallization offers a solution for improved particle characteristics.

Purpose of the Study:

  • To develop vanillin spherical agglomerates using reverse antisolvent crystallization.
  • To elucidate the mechanism of spherical crystallization for vanillin.

Main Methods:

  • Reverse antisolvent crystallization with liquid-liquid phase separation (LLPS).
  • Application of Hansen Solubility Parameters to understand LLPS.
  • In-situ monitoring using the Pixact Crystallization Monitoring system.

Main Results:

  • A six-step mechanism for vanillin spherical crystallization was identified.
  • Optimized working conditions and a frequency-conversion stirring strategy were proposed.
  • Improved flowability and stability of vanillin particles were achieved.

Conclusions:

  • Reverse antisolvent crystallization is effective for producing vanillin spherical agglomerates.
  • Understanding the crystallization mechanism aids in process optimization.
  • The proposed methods enhance vanillin particle quality for industrial applications.