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An adaptive h-refinement method for the boundary element fast multipole method for quasi-static electromagnetic

William A Wartman1, Konstantin Weise2,3, Manas Rachh4

  • 1Electrical and Computer Engineering Department, Worcester Polytechnic Inst., Worcester, MA 01609 United States of America.

Physics in Medicine and Biology
|February 5, 2024
PubMed
Summary

Adaptive mesh refinement (AMR) significantly reduces modeling errors in transcranial electrical stimulation (TES) and electroencephalography (EEG) simulations. This method improves accuracy for brain stimulation and neurophysiological recordings.

Keywords:
adaptive mesh refinementboundary element fast multipole methodboundary element methodelectroencephalographyfast multipole methodtranscranial electrical stimulationtranscranial magnetic stimulation

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Area of Science:

  • Computational neuroscience
  • Biomedical engineering
  • Electrophysiology

Background:

  • Standard multi-compartment head models can produce significant errors in electric field and potential calculations.
  • These errors impact the accuracy of modeling brain stimulation and neurophysiological recordings.

Purpose of the Study:

  • To quantify modeling errors in transcranial magnetic stimulation (TMS), transcranial electrical stimulation (TES), and electroencephalography (EEG) forward problems.
  • To eliminate these errors using an adaptive mesh refinement (AMR) algorithm.

Main Methods:

  • An AMR method was developed and investigated using the boundary element method with fast multipole acceleration (BEM-FMM).
  • The AMR method efficiently allocates additional computational resources to critical model areas.
  • Accuracy was assessed on head models from the Human Connectome Project for TES, TMS, and EEG.

Main Results:

  • The adaptively-refined solutions showed excellent agreement with a 'silver-standard' solution.
  • AMR proved vital for accurate TES and EEG modeling, reducing average errors exceeding 60% with <25% increase in mesh elements.
  • Significant improvements were observed for transcranial electrical stimulation and electroencephalography.

Conclusions:

  • AMR effectively eliminates substantial modeling errors in head models for brain stimulation and neurophysiological recordings.
  • Accurate modeling is crucial for applications like transcranial electrical stimulation dosing and electroencephalography lead field analysis.
  • The AMR approach is expected to be applicable to other numerical modeling packages for electromagnetic simulations.