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Study of Antimicrobial Resistance (AMR) in Shigella spp. in India

Maulikkumar D Vaja1, Heenaben A Chokshi2, Janak J Jansari2

  • 1Department of Pharmaceutical Chemistry, Saraswati Institute of Pharmaceutical Sciences, Near Hotel Anjali Inn, Dhanap, India.

Recent Advances in Anti-Infective Drug Discovery
|February 6, 2024
PubMed

Insights

Antimicrobial resistance (AMR) in Shigella infections is rising in India, complicating treatment and increasing global health risks. Improved surveillance and new therapies are crucial for managing this growing challenge.

Area of Science:

  • Microbiology
  • Epidemiology
  • Public Health

Background:

  • Antimicrobial agents are vital for treating infectious diseases in humans and animals.
  • Antimicrobial drug resistance (AMR) is diminishing the effectiveness of antibiotics, posing a significant global health threat.
  • Shigella spp. are a major cause of diarrheal disease and mortality worldwide, with antibiotic treatment being crucial for management.

Purpose of the Study:

  • To provide a retrospective analysis of AMR in Shigella infections in India.
  • To highlight the increasing trend of antimicrobial resistance in Shigella isolates.
  • To emphasize the need for improved surveillance and novel therapeutic strategies.

Main Methods:

  • Retrospective analysis of epidemiological data on Shigella infections in India.
  • Review of existing literature on antimicrobial resistance patterns in Shigella.
  • Examination of mechanisms contributing to AMR.

Main Results:

  • A significant rise in antimicrobial resistance in Shigella infections in India has been observed.
  • Broad-spectrum antibiotic resistance in Shigella is increasing, making infections harder to treat.
  • Mechanisms of resistance include reduced cell permeability, efflux pumps, and antibiotic-degrading enzymes.

Conclusions:

  • AMR in Shigella infections in India is a growing problem with global implications.
  • There is an urgent need for enhanced surveillance of Shigella infections and the development of new treatment approaches.
  • Addressing AMR requires a multifaceted, cross-sectoral approach involving humans, animals, food, and the environment.
Keywords:
Shigellaantibioticsantimicrobial drug resistanceantimicrobial susceptibilityepidemiologygenomic mechanism.multidrug resistant (MDR) Shigellaoutbreaks in India

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