Topical Noneuphoric Phytocannabinoid Elixir 14 Reduces Inflammation and Mitigates Burn Progression.

Area of Science:

• Burn research
• Dermatology
• Pharmacology

Background:

• Thermal injuries require prompt intervention to reduce inflammation and improve healing.
• Cannabinoids show potential for anti-inflammatory effects and wound healing promotion.
• Noneuphoric Phytocannabinoid Elixir 14 (NEPE14) contains various phytochemicals, including cannabinoids.

Purpose of the Study:

• To investigate the efficacy of topical NEPE14 in mitigating deep partial-thickness burn wounds.
• To assess NEPE14's impact on inflammation and burn wound progression.
• To evaluate NEPE14's effects on bacterial load and wound healing.

Main Methods:

• Deep partial-thickness burns were induced in pigs.
• Treatments included NEPE14, vehicle control, Silverlon, and gauze.
• Burn assessments involved digital photography, Laser-Speckle, MolecuLight imaging, and histological analysis.

Main Results:

• NEPE14 significantly reduced inflammation, specifically interleukin-6 and tumor necrosis factor-α levels (P < 0.001).
• Reduced inflammation correlated with mitigated burn wound progression.
• No significant differences were found in wound healing or bacterial presence.

Conclusions:

• Topical NEPE14 effectively decreased inflammation in deep partial-thickness burns.
• NEPE14 mitigated burn wound progression compared to control treatments.
• Further research may explore NEPE14's role in burn management.