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Multi-modal nanoprobe-enabled biosensing platforms: a critical review.

Tong Li¹, Jiani Zhang¹, Pengzhi Bu¹

¹Chengdu University of Traditional Chinese Medicine, Chengdu, China.

|February 7, 2024

Summary

Multi-modal nanoprobes and biosensors overcome limitations of single-signal systems by integrating multiple detection methods. This advancement enhances performance in pharmaceutical, food, and environmental sensing applications.

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Area of Science:

Materials Science
Biotechnology
Analytical Chemistry

Background:

Single-modal nanoprobes and biosensors face limitations in sensitivity and reliability.
Nanomaterials offer unique properties for biosensing but single-signal mechanisms are restrictive.

Purpose of the Study:

To review the current status and classification of multi-modal nanoprobes.
To discuss multi-modal signal sensing mechanisms and biosensing platforms.
To highlight applications and future prospects in multi-modal biosensing.

Main Methods:

Review of multi-modal nanoprobes and their signal outputs (fluorescence, colorimetric, electrochemical, magnetic).
Analysis of sensing mechanisms and working principles of multi-modal biosensing platforms.
Exploration of applications in pharmaceutical detection, food safety, and environmental monitoring.

Main Results:

Multi-modal nanoprobes compensate for single-modal defects by integrating composite nanomaterials.
Multi-modal biosensors achieve enhanced performance beyond single-signal limitations.
Demonstrated utility in diverse fields including pharmaceutical, food, and environmental analysis.

Conclusions:

Multi-modal nanoprobes and biosensors represent a significant advancement in sensing technology.
The integration of multiple signals offers superior detection capabilities.
Future development holds promise for improved analytical tools and applications.