THE ROLE OF COENZYME COQ10 AND VITAMIN E IN PATIENTS WITH BETA-THALASSEMIA MAJOR IN BAGHDAD CITY POPULATION

Our study aimed to evaluate the level of coenzyme (CoQ10) in the plasma of human which suffered from beta-thalassemic major disease and vitamin E concentration in comparison to control cases. We included 90 (60 β-TM patients and 30 persons for control groups). The range of age (15-40 years) during the period from December 2022 to March 2023, and the study included patients previously diagnosed with beta-thalassemia major from Medical City and Karama Hospital. The level of serum CoQ10 in the patients was 2.02 ng/ml and in the control, groups were 3.55 ng/ml. The difference was statically high between the two groups (P<0.001). Likewise, our study includes the concentration of vitamin E in the study groups (patients 2.29 ng/ml and for control cases 7.25 ng/ml). The results highlight that there was a highly significant difference between the two groups (P<0.001). In conclusion, for both β-TM patients and control groups, the results show that the two parameters CoQ10 and vitamin E were highly significant difference((P<0.001) which means there were lower antioxidant capacities as demonstrated by the results of our new study.