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Carboxyl-Modified Quantum Dots for NIR-IIb Bone Marrow Imaging.

Peng Zhang1,2, Yuran Wang1, Xiaotong Liu1

  • 1Biomaterials Research Center, School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, China.

ACS Applied Materials & Interfaces
|February 8, 2024
PubMed
Summary
This summary is machine-generated.

Carboxyl-rich fluorescent nanoprobes target bone marrow macrophages for in vivo optical imaging. This novel strategy enables high-resolution bone imaging and fracture diagnosis, advancing noninvasive bone health assessment.

Keywords:
NIR-II fluorescence imagingbone marrow imagingmacrophagenanoprobesquantum dots

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Area of Science:

  • Biomedical Engineering
  • Optical Imaging
  • Nanotechnology

Background:

  • Noninvasive bone imaging requires specific bone-targeting probes.
  • Current methods may lack resolution or penetration depth for comprehensive bone assessment.

Purpose of the Study:

  • To develop carboxyl-rich fluorescent nanoprobes for in vivo optical bone marrow imaging.
  • To evaluate the efficacy of these nanoprobes for imaging-guided fracture diagnosis.

Main Methods:

  • Preparation of carboxyl-rich nanoprobes using PbS/CdS core-shell quantum dots emitting in the NIR-IIb (1500-1700 nm) window.
  • In vivo NIR-IIb fluorescence imaging in bone tissues.
  • Histological analysis of bone tissue slices to assess nanoprobe accumulation and colocalization with macrophages.

Main Results:

  • Carboxyl-rich nanoprobes were readily absorbed by bone marrow macrophages in vivo.
  • High-resolution imaging of bone tissues with significant penetration depth was achieved.
  • Successful imaging-guided diagnosis of bone fractures was demonstrated.
  • Substantial accumulation of nanoprobes in bone marrow and colocalization with macrophages were confirmed.

Conclusions:

  • Carboxyl surface modification is an effective strategy for bone marrow targeting.
  • The developed nanoprobes offer a novel approach for noninvasive bone and bone marrow imaging.
  • This strategy holds promise for improved bone health monitoring and fracture diagnosis.